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Platelet-derived exosome serums developed by Mayo Clinic scientists to visibly renew skin — a popular post-procedure and daily regenerative topical. See it simulated, mapped to the treatments it powers, and built into a plan.
Sarah Jenkins
Plan • Skincare
Recommended Protocol
Plated
Platelet-derived exosome serums
Maintenance & Follow-Up
Ongoing plan
Plated (by Rion) is a line of topical serums powered by platelet-derived exosomes, developed by Mayo Clinic scientists. Applied topically — often after microneedling or laser — it targets the look of fine lines, redness, brown spots, and texture with results that build over weeks. It's a cosmetic skincare product, not an injectable or FDA-approved drug.
Understanding Plated
Plated is a line of topical serums built around platelet-derived exosomes — nanosized vesicles that signal skin to renew — developed by Mayo Clinic physician-scientists over two decades of research. Applied topically (often after microneedling, laser resurfacing, or as part of a daily routine), the serums aim to improve the look of fine lines, redness, brown spots, tone, and texture, with results that build over weeks. Its INTENSE Serum was named a TIME Best Invention and is widely stocked by injectors, dermatologists, and plastic surgeons as a regenerative complement to in-office treatments.
For a practice, Plated is a high-margin retail and post-procedure add-on that extends the result of a laser or microneedling session and keeps patients engaged with their plan between visits. Framing it as the at-home step that protects and amplifies an in-clinic investment — and showing where it fits on the patient's roadmap — turns a single treatment into an ongoing regimen and a recurring purchase.
Quick Facts
Plated
Made by
Rion (Plated Skin Science)
Category
Platelet-derived exosome serums
Type
Topical / skincare product
US regulatory status
Sold as a topical cosmetic; exosome serums are not FDA-approved and are applied topically, not injected.
From the treatment room
Provider perspectives on Plated
Morgan Gale, MSN, NP
Founder & Owner
Aesthetic Artistry Laser Center
North Bethesda, MD
In their words
“I love the biologics — the exosomes, the PDGF. Those are my adjunct to everything now, because they recruit the fibroblast activity that helps to create the collagen I'm after.”
Plated is how practices deliver exosome cellular renewal
See the full treatment category — what it does, the concerns it solves, and how it fits into a visual 12-month plan.
Concerns Plated addresses
Each concern maps to its full range of options — and lets patients preview their result before they commit.
Fine Lines
Small, shallow wrinkles that show up first around the eyes, mouth, and forehead.
Explore concernSkin Texture - Face
Smoothing rough, uneven, or bumpy facial skin for a refined, radiant complexion.
Explore concernUneven Skin Tone - Face
Patchy discoloration, blotchiness, and dark spots that leave the complexion looking uneven and lacking clarity.
Explore concernDull Skin - Face
A tired, lackluster complexion lacking radiance from dehydration, dead-skin buildup, and environmental stress.
Explore concernAcne Scars
Pits, raised marks, and discoloration left behind after breakouts heal.
Explore concernUnder Eye Circles
Brightening dark circles, shadows, and hollows that make the under-eye look tired.
Explore concernCrepey Skin
Thin, finely wrinkled skin resembling crepe paper, common on the under-eyes, neck, arms, and décolletage.
Explore concernPlated questions, answered
Common questions patients ask about Plated — and what practices should be ready to answer.
What are platelet-derived exosomes?
Exosomes are nanosized vesicles that carry signaling cargo between cells. Plated's platelet-derived exosomes are formulated into a topical serum intended to prompt the skin's own renewal, improving the look of aging and damaged skin over time.
Is Plated injected?
No — Plated is a topical serum applied to the skin, commonly after microneedling or laser resurfacing to support recovery and results, or as part of a daily routine. It is not an injectable.
When do you see results with Plated?
Many users see improved glow within a few weeks, with benefits that continue to build with consistent use as part of a broader skincare and treatment plan.
Brands similar to Plated
Patients weigh their options by name. Browse the alternatives Afters can visualize and plan.
Toskani
A professional skincare line of PDRN, growth-factor, and targeted cocktail serums used to boost skin quality alongside in-office treatments.
View brandRejuran
A polynucleotide 'salmon DNA' injectable popular in Korea for repairing skin from within.
View brandTurn Plated interest into booked, recurring revenue
Afters gets you found for it, simulates the result, and builds the plan that lifts average ticket and visit frequency — software and specialist team included.